Job Description

Senior Scientist / Associate Director, Biochemical and Cellular Assay Technologies, Discovery Sciences

Location: Boston

We are seeking a Discovery Sciences Team Lead (Senior Scientist or Associate Director) responsible for biochemical and cellular assays. The Team Lead will contribute across the discovery spectrum from Lead Discovery to Development Candidate. The person will be responsible for the design and execution of biochemical and cellular assays for hit finding, hit validation, mechanism of action studies and medicinal chemistry profiling. The ideal candidate has a high level of experience in directing innovative approaches in the area of biochemical and cellular assays, preferably including the design of physiologically relevant assays in a high-throughput setting. A proven track record of enabling drug discovery teams with high quality data focused on discovery path is required. The ideal candidate must be exceedingly well organized, highly motivated, able to motivate others, have outstanding interpersonal skills and be extremely flexible. The candidate should be recognized in the community for their high degree of innovation and quality of science. The candidate must also bring a high level of enthusiasm for working in a fast-paced and dynamic environment.

Principal Duties and Responsibilities

• Design, develop, and implement cellular and/or biochemical assays suitable for the identification, characterization and optimization of compounds. These assays will enable project teams to evaluate the compounds and develop structure-activity relationships as part of the overall lead discovery and optimization activities.
• Contribute to the vision & establish and manage the workflows for Discovery Sciences that enables productivity, creativity, and integrates new technologies to ensure that Discovery Sciences operates at the leading edge of drug discovery.
• Generate innovative proposals and drive the implementation of new technological approaches and capabilities.
• Create project plans and execute workflows and logistics to meet project goals and milestones.
• Set scientific direction for the group and contribute to managing priorities of company’s portfolio.
• Works with leadership team to ensure strategic plans align with corporate goals and long-term company plans.
• Provides coaching and leadership to a team of bench-oriented scientists performing lead discovery activities.
• This role will be 40%-60% in the lab based

Qualifications

• Ph.D. in Enzymology, Biochemistry, Biology, or related field or equivalent pharmaceutical/biotech experience is required.
• Experience with developing biochemical and cellular assays for lead discovery and optimization is required.
• Experience working in a drug discovery environment is preferred.
• In-depth knowledge of assay design principles is required, and experience with HTS is preferred.
• Experience with compound screening formats, laboratory instrumentation and automation, data analysis and management, and a sound knowledge of the drug discovery process is preferred.
• Proven track record for striving for high level of innovation and scientific excellence.
• Excellent management, training and education skills.

Interested candidates should forward CV and cover letter to careers-us@monterosatx.com or apply on line

About Monte Rosa

Monte Rosa Therapeutics is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases in the areas of oncology, autoimmune and inflammatory diseases, and more. MGDs are small molecule protein degraders that have the potential to treat many diseases that other modalities, including other degraders, cannot. Monte Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology and proteomics to identify degradable protein targets and rationally design MGDs with unprecedented selectivity. The QuEEN discovery engine enables access to a wide-ranging and differentiated target space of well-validated biology across multiple therapeutic areas. Monte Rosa has developed the industry’s leading pipeline of MGDs, which spans oncology, autoimmune and inflammatory disease and beyond, and has a strategic collaboration with Roche to discover and develop MGDs against targets in cancer and neurological diseases previously considered impossible to drug. For more information, visit

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